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Time trends, disease patterns and gender imbalance in the top 100 most cited articles in ophthalmology
16.07.2018
Survival Rates in Patients After Treatment for Metastasis From Uveal Melanoma
04.07.2018
Improving Reporting Quality in Ophthalmologic Observational Studies That Use Big Data
In recent years, there has been an explosion of research articles using large population databases in clinical research; ophthalmology is no exception. In 2012, using the British Columbia Ministry of Health database, we published one of the first population-based pharmacoepidemiologic studies1 that found an elevated risk of retinal detachment (RD) (relative risk, 4.50; 95% CI, 3.56-5.70) with oral fluoroquinolones (FQs). Since 2012, several large epidemiological studies on this topic have been published with conflicting results. 03.05.2018
Systemic Medication Associations with Presumed Advanced or Uncontrolled Primary Open-Angle Glaucoma
We present data documenting potential associations of SSRIs and calcium channel blockers with POAG requiring a procedure. Further research may be indicated to better evaluate any associates of serotonin metabolism or calcium channels in glaucoma, or establish whether the associations are due to variations in the patterns for prescribing these drugs. 02.05.2018
Mechanisms of macular edema: Beyond the surface
Macular edema consists of intra- or subretinal fluid accumulation in the macular region. It occurs during the course of numerous retinal disorders and can cause severe impairment of central vision. Major causes of macular edema include diabetes, branch and central retinal vein occlusion 16.04.2018
Visual and Refractive Outcomes in Manual versus Femtosecond Laser-Assisted Cataract Surgery: A Single-Center Retrospective Cohort Analysis of 1838 Eyes
Postoperatively, there was no statistically significant difference found between eyes undergoing FLACS and eyes undergoing MCS with respect to refractive and visual outcomes. 12.04.2018
Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe in 2015: magnitude, temporal trends and projections
While continuing to advance control of cataract and AMD as the leading causes of blindness remains a high priority, overcoming barriers to uptake of refractive error services would address approximately half of the MSVI burden. New data on burden of presbyopia identify this entity as an important public health problem in this population. Additional research on better treatments, better implementation with existing tools and ongoing surveillance of the problem is needed. 09.04.2018
Scientists Find Very Young Cells in Even Very Old Brains
That's a big deal. For decades, researchers believed that aging brains stop making new cells. But recent research has offered strong evidence to the contrary, and a new paper published today (April 5) in the journal Cell Stem Cell tries to put the notion to bed entirely. Aging brains, the researchers showed, produce just as many new cells as younger brains do. 09.04.2018
Surgical Outcomes of Epiretinal Membranes in Patients with a History of Well-Controlled Preoperative Uveitis
Eyes with a history of controlled uveitis have low surgical recurrence rates that are comparable with those without uveitis. Most patients do not require escalation of immunomodulatory therapy after surgery. 09.04.2018
Long-term surgical outcomes for large-angle, infantile esotropia
The overall success rate for treatment of large-angle, infantile esotropia was poor in this cohort, with most failures due to recurrent or residual esotropia. Botulinum toxin-augmented surgery was associated with a higher success rate at final follow-up. 26.03.2018
Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 1 Year of Follow-up.
Trabeculectomy with MMC had a higher surgical success rate than tube shunt implantation after 1 year in the PTVT Study. Lower IOP with use of fewer glaucoma medications was achieved after trabeculectomy with MMC compared with tube shunt surgery during the first year of follow-up. The frequency of serious complications producing vision loss or requiring reoperation was lower after tube shunt surgery relative to trabeculectomy with MMC. 22.03.2018
Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 1 Year of Follow-up
Trabeculectomy with MMC had a higher surgical success rate than tube shunt implantation after 1 year in the PTVT Study. Lower IOP with use of fewer glaucoma medications was achieved after trabeculectomy with MMC compared with tube shunt surgery during the first year of follow-up. The frequency of serious complications producing vision loss or requiring reoperation was lower after tube shunt surgery relative to trabeculectomy with MMC. 18.03.2018
Visual Field Progression Is More Complicated Than Meets the Eye
the authors examined the longitudinal differences in perimetric testing in ancestry groups and determined that patients of African ancestry showed greater variability in visual field testing than individuals of European ancestry. As the authors noted, this finding and its underlying mathematical modeling suggests that delayed detection of progression of visual impairment may occur in patients of African descent. 08.03.2018
The SCORE2 Comparison of Treat-and-Extend vs Monthly Anti–Vascular Endothelial Growth Factor Dosing Short-term Similarities and Longer-term Questions
Therapy with anti–vascular endothelial growth factor (anti-VEGF) agents has dramatically improved visual outcomes for patients with various retinal vascular diseases, including retinal vascular occlusion, diabetic macular edema, and neovascular age-related macular degeneration. 28.02.2018
New developments in optical coherence tomography imaging for glaucoma
Since its introduction in ophthalmology, optical coherence tomography (OCT) has undergone significant advances in imaging protocols, algorithms, and addition of new parameters which have maximized its potential for diagnosing, evaluating the response to treatment, and assessing the progression of various ocular diseases, including glaucoma. This review provides an update on recent developments in OCT with respect to the management of glaucoma. 22.02.2018
Phantom Eye Patients See and Feel with Missing Eyeballs
Amputees often feel eerie sensations from their missing limbs. These “phantom limb” feelings can include pain, itching, tingling, or even a sense of trying to pick something up. Patients who lose an eye may have similar symptoms—with the addition of actual phantoms. 18.02.2018
Correlation Between Noninvasive Ultrasonography and Dynamically Monitored Intracranial Pressure
Direct measurements of intracranial pressure (ICP) by lumbar puncture (LP) remain the criterion standard for diagnosing, following, and treating specific neurologic, neurosurgical, and neuro-ophthalmic conditions with elevated ICP. In this issue of JAMA Ophthalmology, Wang et al1 used ultrasonography to document optic nerve sheath diameter (ONSD), and their results reported a correlation between noninvasive ultrasonography and dynamically monitored ICP. 15.02.2018
Systemic lupus erythematosus and ocular involvement: an overview
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease of undefined etiology and with remarkably heterogeneous clinical features. Virtually any organ system can be affected, including the eye. 11.02.2018
Evidence Based Insights Into the Utility of Conjunctival Biopsy in MMP
Eminence-based consensus guidelines can be useful and potentially keep us out of legal trouble, but there is nothing like an evidence-based approach to disease management. 08.02.2018
Statins May Help Prevent Scar Tissue in the Eye After a Vitrectomy
HELSINKI, Finland -- January 18, 2018 -- Statins appear to reduce the risk of repeated surgery in patients who undergo a vitrectomy to treat a detached retina. 05.02.2018
Aflibercept, bevacizumab or ranibizumab for diabetic macular oedema: recent clinically relevant findings from DRCR.net Protocol T
When initial visual acuity loss is mild, there are no apparent differences, on average, among aflibercept, bevacizumab and ranibizumab for treating DME. When visual acuity loss is moderate or worse, aflibercept is more likely to improve visual acuity. 01.02.2018
INTERNAL LIMITING MEMBRANE PEELING VERSUS INVERTED FLAP TECHNIQUE FOR TREATMENT OF FULL-THICKNESS MACULAR HOLES: A COMPARATIVE STUDY IN A LARGE SERIES OF PATIENTS.
Vitrectomy associated with the inverted ILM flap technique seems to be effective surgery for idiopathic and myopic large MHs, improving both functional and anatomical outcomes. 28.01.2018
Cataract Surgery From 1918 to the Present and Future—Just Imagine!
Acknowledging and appreciating the past contributions of pioneers in cataract surgery is vital to understanding the development of today's clinical care. Clues as to the future do help give us a possible scenario worthy of such conjecture. 25.01.2018
Cataract surgery in patients with diabetes
Cataract continues to be the leading cause of blindness according to the Global Burden of Disease, Injuries and Risk Factors Study.A The World Health Organization estimates that the number of cases of blindness from cataract will increase to 40 million in 2025 as a result of aging population and longer life expectancies. 25.01.2018
Using Local Therapy to Control Noninfectious Uveitis
Direct access to the intraocular space means the eye is an ideal organ for local therapy, achieving high drug concentration on target. 22.01.2018
Pediatric Keratoprosthesis: A Promise Unfulfilled
Until we have a better understanding of how to improve KPro outcomes in children, corneal surgeons should “just say no.” 18.01.2018
EXIT STRATEGY IN A TREAT-AND-EXTEND REGIMEN FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION
The high percentage of patients meeting the exit criteria and the relatively low incidence of recurrences underline the usefulness of a predefined exit strategy. However, in a subgroup of patients, continuation of therapy may be advisable. 14.01.2018
Lessons From Recent Randomized Clinical Trials of Binocular Treatment for Amblyopia-editorial
Those of us who see and treat children and adults with amblyopia were initially enthused by the findings of previous case series2 suggesting that a binocular approach to treating amblyopia was effective, targeting suppression without patching or atropine sulfate. 11.01.2018
Effectiveness of a Binocular Video Game vs Placebo Video Game for Improving Visual Functions in Older Children, Teenagers, and Adults With Amblyopia A Randomized Clinical Trial
Is a home-based binocular video game more effective than a placebo video game for improving amblyopic eye visual acuity in older children and adults with unilateral amblyopia? 11.01.2018
דימום תוך עיני כביטוי של זיהום חד בנגיף אפשטיין-בר
זיהום בנגיף אפשטיין־בר עשוי להביא למכלול נרחב של ביטויים קליניים. דימומים תת־לחמיתיים דו צדדיים הם ביטוי נוסף לפגיעה מנגיף זה. 08.01.2018

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