Veldman PB, Greiner MA, Cortina MS, Kuo AN, Li JY, Miller DD, Shtein RM, Weikert MP, Yin J, Kim SJ, Shen JF.
Ophthalmology. 2025 Feb;132(2):154-163. doi: 10.1016/j.ophtha.2024.08.021. Epub 2024 Oct 10.
PMID: 39387749 Review.
FULL ARTICLE
Abstract
Objective: To evaluate the published literature on the efficacy of amniotic membrane grafting (AMG) in the management of acute chemical and thermal ocular surface burns with respect to the rate of corneal re-epithelialization and improvement of visual acuity or corneal clarity.
Methods: Literature searches were conducted in the PubMed database in May 2023 and updated in January 2024 and were limited to the English language without date restrictions. The searches yielded 474 citations; 58 were reviewed in full text, and 9 met the inclusion criteria. Four studies were rated level II, and 5 studies were rated level III. This assessment focuses on 3 level II articles that provided consistent primary and secondary outcomes but demonstrated suboptimal study design with respect to power calculations and lacked a priori sample-size calculations.
Results: Amniotic membrane grafting significantly improved corneal re-epithelialization compared with medical therapy alone in eyes with moderate-grade burns. For severely burned eyes, AMG demonstrated no advantage over medical therapy. Additionally, AMG demonstrated no significant advantage over medical therapy for improved visual acuity or corneal clarity for moderate or severe ocular surface burns.
Conclusions: The best available level II evidence suggests that AMG in the setting of acute ocular surface burns has efficacy in hastening re-epithelialization in moderate burns. As an adjuvant to medical therapy, it did not demonstrate a benefit in improving re-epithelialization in severe burns or visual acuity or corneal clarity in either moderate or severe burns.
Financial disclosure(s): Proprietary or commercial disclosure may be found after the references.
Keywords: Adjuvant therapies; Amniotic membrane; Corneal epithelium; Limbal stem cell; Ocular surface injuries.
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