Characterization of Central Visual Field Loss in End-stage Glaucoma by Unsupervised Artificial Intelligence Although the central visual field (VF) in end-stage glaucoma may substantially vary among patients, structure-function studies and quality-of-life assessments are impeded by the lack of appropriate characterization of end-stage VF loss. We provide a quantitative characterization and classification of central VF loss in end-stage glaucoma. This retrospective cohort study collected data from 5 US glaucoma services from June 1, 1999, through October 1, 2014. A total of 2912 reliable 10-2 VFs of 1103 eyes from 1010 patients measured after end-stage 24-2 VFs with a mean deviation (MD) of −22 dB or less were included in the analysis. Data were analyzed from March 28, 2018, through May 23, 2019.